Westford, Mass. - October 27, 2003 - MatrixOne, Inc. (NASDAQ: MONE), a leading provider of collaborative product lifecycle management (PLM) solutions, today announced that Possis Medical, Inc. (Nasdaq:POSS) a leading developer and manufacturer of pioneering medical devices for the cardiovascular and vascular treatment markets, has chosen Matrix10™ as the foundation for its product development environment. Possis will use Matrix10, the industry's most flexible PLM solution, to manage its new product pipeline process, migrate from paper-based to automated electronic processes for new product development, and speed compliance with FDA regulations including Title 21 CFR Part 11, which prescribes the accepted use of electronic records and signatures in medical device manufacturing.

"We selected MatrixOne for its scalability and track record in helping medical device companies drive product innovation while ensuring regulatory compliance," said Jim Gustafson, Vice President of Technology, Product Development, and Quality Systems for Possis. "One of our key corporate goals is to expand the use of our products by capturing additional FDA approved indications, and to continuously introduce innovative new products which save lives. We believe that MatrixOne solutions are well-suited to help us both optimize the regulatory compliance process, and make our product development and engineering documentation systems most efficient."

Possis Medical, Inc. is pioneering mechanical thrombectomy, which pertains to the rapid, safe and effective removal of blood clots from native arteries, as well as from synthetic and saphenous vein grafts. The company was recently ranked 10th overall among Forbes Magazine's "25 Fastest-Growing Tech Companies" in 2003, and was the top company marketing cardiovascular medical devices, which according to Forbes are the largest medical markets where growth will be driven by continuing innovation and favorable demographics worldwide.

Possis plans to implement MatrixOne PLM solutions that have been packaged and optimized to ensure rapid deployment, including pre-defined process templates, project structures and medical-device industry-specific schema. These solutions include:

• MatrixOne Engineering Central™
  Provides companies with the ability to electronically manage all engineering content including parts, assemblies, Bills of Materials (BOMs) and CAD models and document creation and control. It also allows these companies to manage the Device Master Record (DMR), a critical component of Rule 21 CFR Part 11, compliance.

   

• MatrixOne Program Central™
  Helps manage a company's global development program by providing out-of-the-box templates for design control phases, including feasibility, design and development, clinical evaluation through production and commercialization.

   

• MatrixOne Document Central™
  Provides companies with the ability to control the management and distribution of all non-product related information such as internal procedures and quality documents and other internal documents.

   

• Matrix PLM Platform™
  Provides a proven, standards-based offering that is equipped with the industry's highest level of performance and security, making it the perfect solution for companies in all industries, including the medical device industry.

About Possis Medical
Possis Medical Inc. develops, manufactures and markets pioneering medical devices for the large and growing cardiovascular and vascular treatment markets. Its primary product, the AngioJet Rheolytic Thrombectomy System, is marketed in the United States for blood clot removal from coronary arteries and bypass grafts, leg arteries and AV dialysis access grafts. For more information go to www.possis.com

About MatrixOne
MatrixOne, Inc. (NASDAQ: MONE) is a recognized leader in delivering collaborative Product Lifecycle Management (PLM) solutions. We provide flexible solutions that unleash the creative power of global value chains to inspire innovations and speed them to market. MatrixOne's customers include global leaders in the aerospace and defense, automotive, consumer products, high technology, life sciences, machinery, and the process industries, including Agilent Technologies, General Electric, Honda, Johnson Controls, Philips, Procter & Gamble, Siemens, and Toshiba. MatrixOne (http://www.matrixone.com/) is headquartered in Westford, Massachusetts with locations throughout North America, Europe, and Asia/Pacific.

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MatrixOne, the MatrixOne logo and eMatrix are registered trademarks, and a leading provider of collaborative product lifecycle management (PLM) solutions for the value chain, and MatrixOne Engineering Central are trademarks of MatrixOne, Inc. All other trademarks and service marks are the property of their respective owners.

Forward-looking statements in this release are subject to risks and uncertainties that could cause our actual results to differ materially from those anticipated. Such statements may relate, among other things, to our plans, objectives and expected financial and operating results. The risks and uncertainties that may affect forward-looking statements include, among others: poor product sales, long sales cycles, difficulty developing new products, difficulty in relationships with vendors and partners, higher risk in international operations, difficulty assimilating future acquisitions, difficulty managing rapid growth, and increased competition. For more about the risks and uncertainties of our business, see our periodic and other S.E.C. filings.